Is 'The Last of Us' Real? Expert Reveals Science Behind the Fungal Apocalypse

The Last of Us' Fungal Apocalypse: Fact vs. Fiction In a recent video by Science News, senior molecular biology writer Tina Hesman Saey explores the scientific accuracy of HBO's hit show, "The Last of Us." The video, uploaded on May 26th, 2025, has already garnered significant views and likes, indicating strong public interest. Saey highlights several ways the show reflects real-world science, such as the existence of cordyceps fungi that can control insects. "The cordyceps fungus that takes over human brains in the show is based on a real genus of fungi," explains Saey. The video further examines the impact of climate change on fungal infections, noting that warming temperatures are expanding suitable habitats for fungal growth. Saey also discusses the possibility of human immunity to certain fungi and the ever-present fungal spores in the air we breathe. However, she emphasizes that, unlike the show's depiction, a successful fungal vaccine remains elusive. The video's factual basis and expert commentary make it a valuable resource for understanding the science behind the fictional narrative.